Updates | Bigley Lab

Lab helps to identify the tropism of roseolovirus (Links to an external site)

June 4, 2024August 16, 2024

The Bigley lab, in collaboration with Michael Paley’s lab, identify the tropism of roseolovirus in the thymus and the resultant molecular dysregulation. Transcriptomic profiling of thymic dysregulation and viral tropism after neonatal roseolovirus infection June 4, 2024 Belean A, Xue E, Cisneros B, Roberson EDO, Paley MA, Bigley TM. Transcriptomic profiling of thymic dysregulation and […]

Collaboration characterizes the molelucar mechanism of C-terminal COPA variants (Links to an external site)

January 4, 2024February 16, 2024

The Bigley lab collaborates with Selket Delagontaine in the Meyts lab to show how C-terminal domain variant in COPA result in autoinflammation due to increased ER stress.

Bigley lab publishes phenotype expansion of IKAROS GOF (Links to an external site)

December 22, 2023January 19, 2024

This characterization of a rare inborn error of immunity demonstrates a phenotypic expansion to include necrobiotic xanthogranuloma.